The untranslated regions (UTRs) of mRNA can have important roles in regulating protein production because they contain the instructions for determining the protein production efficiency and how long a given mRNA molecule will live within the cell. We identify target proteins of potential biological and medical relevance to human disease and assess their regulation through UTRs and clinical feasibility. For targets that we select, we precisely identify the UTRs of the target gene. We use proprietary assays to test our library of approximately 240,000 compounds to identify those that are likely to enhance or inhibit expression of the target.

The untranslated regions (UTRs) of a messenger or mRNA (shown above in red and indigo) sit on both sides (ie, 5' and 3') of the mRNA's reading frame and contribute to the regulation of protein production.

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